Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

NSAID gastroenteropathy: past, present and future

J L Wallace1

  • 1Intestinal Disease Research Unit, Faculty of Medicine, University of Calgary, Alberta. wallacej@acs.ucalgary.ca

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
|November 1, 1996
PubMed
Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs) can harm the gastrointestinal tract. New NSAIDs are being developed to target specific enzymes, aiming to reduce gastrointestinal toxicity and improve patient safety.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[TRENDS IN DEVELOPMENT OF GI-SAFE ANTI-INFLAMMATORY DRUGS].

Klinicheskaia meditsina·2018
Same author

The effect of hydrogen sulfide-releasing naproxen (ATB-346) versus naproxen on formation of stress-induced gastric lesions, the regulation of systemic inflammation, hypoxia and alterations in gastric microcirculation.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2018
Same author

Glyprolines exert protective and repair-promoting effects in the rat stomach: potential role of the cytokine GRO/CINC-1.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2016
Same author

Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2013
Same author

Dextran sulfate sodium induces pan-gastroenteritis in rodents: implications for studies of colitis.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2012
Same author

Representation of three-dimensional objects by the rat perirhinal cortex.

Hippocampus·2012

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Drug Development

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) pose significant gastrointestinal toxicity risks, limiting their therapeutic use for inflammatory conditions.
  • NSAID enteropathy and gastroenteropathy are serious adverse effects that necessitate the development of safer alternatives.
  • Understanding the mechanisms of NSAID-induced gut damage is crucial for designing improved anti-inflammatory therapies.

Purpose of the Study:

  • To review the pathogenesis of NSAID-induced gastrointestinal damage.
  • To examine past, current, and future strategies for developing NSAIDs that minimize gastrointestinal toxicity.
  • To highlight the role of targeting specific prostaglandin synthase enzymes in creating safer NSAIDs.

Main Methods:

Related Experiment Videos

  • Review of existing literature on NSAID toxicity and enteropathy.
  • Analysis of strategies employed in the development of novel NSAIDs.
  • Focus on the identification and characterization of inducible prostaglandin synthase.

    • Main Results:

    • The pathogenesis of NSAID gastroenteropathy is complex and involves multiple factors.
    • Targeting the inducible form of prostaglandin synthase has enabled the design of novel NSAIDs with reduced gastrointestinal side effects.
    • Significant progress has been made in developing NSAIDs that spare the gastrointestinal tract.

    Conclusions:

    • Developing NSAIDs with improved gastrointestinal safety profiles is a key therapeutic goal.
    • Targeting specific enzymes like inducible prostaglandin synthase represents a promising strategy for safer NSAID design.
    • Continued research into NSAID pathogenesis and drug design is essential for advancing anti-inflammatory treatments.