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Anticipation of onset age in hereditary essential tremor
M Bragoni1, G Fabbrini, S Di Legge
1Dipartimento di Scienze Neurologiche; V Clinica Neurologica, Università degli Studi di Roma La Sapienza, Roma, Italy.
Italian Journal of Neurological Sciences
|February 1, 1997
Abstract:
The genetic anticipation phenomenon has been described in several neurological disorders, often associated with unstable trinucleotide repeats in the affected genes. The occurrence of this phenomenon in hereditary essential tremor is still debated. We describe a family in which three male members with essential tremor showed a progressive anticipation in onset age and an increased severity of clinical symptomatology.