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Related Experiment Videos

Tics associated with autistic and pervasive developmental disorders

J S Stern1, M M Robertson

  • 1Department of Neurology, MRC Cyclotron Unit, Hammersmith Hospital, London, the United Kingdom.

Neurologic Clinics
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

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Tourette syndrome and Pervasive Developmental Disorders co-occur frequently. Some research suggests Tourette syndrome may contribute to the genetic diversity observed in Pervasive Developmental Disorders, though evidence is debated.

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Increasing reports link Tourette syndrome (TS) and Pervasive Developmental Disorders (PDD).
  • Approximately 90 cases of co-occurrence have been documented.
  • A subset of these cases shows familial patterns of TS and tics.

Purpose of the Study:

  • To review the literature on the co-occurrence of Tourette syndrome and Pervasive Developmental Disorders.
  • To explore the neurobiological underpinnings of both conditions.
  • To evaluate the hypothesis that TS contributes to PDD genetic heterogeneity.

Main Methods:

  • Literature review of published studies on TS and PDD co-occurrence.
  • Analysis of neurobiological aspects relevant to both TS and PDD.

Related Experiment Videos

  • Synthesis of arguments for and against the proposed genetic link.

    • Main Results:

    • The co-occurrence of Tourette syndrome and Pervasive Developmental Disorders is a recognized phenomenon.
    • Familial aggregation of Tourette syndrome in some PDD cases suggests a potential genetic connection.
    • Neurobiological data offers insights into the shared and distinct features of both disorders.

    Conclusions:

    • The hypothesis that Tourette syndrome contributes to PDD genetic heterogeneity warrants further investigation.
    • Understanding the relationship between TS and PDD is crucial for diagnosis and treatment.
    • Continued research into the neurobiology and genetics of both conditions is necessary.