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Updated: Aug 6, 2026

Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain
R F Cowburn1, C J Fowler, C O'Neill
1Alzheimer's Disease Research Centre, Karolinska Institute, Department of Clinical Neuroscience and Family Medicine, NOVUM, Huddinge, Sweden.
Abstract:
Recent evidence suggests that the neurochemical pathology of Alzheimer's disease includes severe disruptions of the neurotransmitter receptor/G-protein mediated phosphatidylinositol hydrolysis and adenylyl cyclase signal transduction pathways. The present article briefly reviews evidence from postmortem studies describing disruptions to these systems and speculates as to the importance of these changes in terms of contributing to disease pathology and limiting the success of neurotransmitter replacement strategies.
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