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Updated: Aug 4, 2026

Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
Glial cell derived neurotrophic factors and Alzheimer's disease
A J Patel1, C Wickenden, A Jen
1Department of Biochemistry, Charing Cross and Westminster Medical School, London. a.patel@cxivms.ac.UK
Abstract:
In Alzheimer's disease the normal balance of metabolic pathways regulating trophic factors/cytokines is disrupted; local reduction may result in neurons being deprived of neurotrophic factors while an excess may initiate a cascade of interaction between glial cells and beta-amyloid precursor protein metabolism thereby facilitating plaque formation. This paper briefly discusses the findings of our group on aspects ranging from cholinergic humoral and trophic factors to mechanisms underlying amyloidogenesis in Alzheimer's disease.
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