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Lysosomal membrane stabilization by alpha-tocopherol against the damaging action of Vipera russelli venom
A K Mukherjee1, S K Ghosal, C R Maity
1Department of Biochemistry, Burdwan Medical College, India.
Cellular and Molecular Life Sciences : CMLS
|February 1, 1997
Abstract:
This investigation shows the membrane stabilizing effect of alpha-tocopherol against the damaging action of viper venom phospholipase A2 (PLA2). Liver lysosomal membranes from rats fed 100 mg and 200 mg alpha-tocopherol acetate per kilogram of diet were more resistant to damage by viper venom PLA2 compared with vitamin E-deficient rats. The membrane stabilizing effect of vitamin E is proposed to be due to the formation of a complex with the phospholipid hydrolysis products of the membrane.