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An efficient and robust PC program to calculate MR based regional cerebral blood volume maps
T Hackländer1, J R Reichenbach, J Weule
1Department of Diagnostic Radiology, Heinrich-Heine-University, Düsseldorf, Germany. hacklaen@uni-duesseldorf.de
Summary
This study introduces an efficient algorithm for calculating regional cerebral blood volume (rCBV) using MRI. This method provides quantitative functional information for assessing brain alterations and enables both visual inspection and local evaluation.
Area of Science:
- Neuroimaging
- Medical Physics
- Radiology
Background:
- Functional brain information is crucial for assessing pathological alterations.
- Magnetic Resonance Imaging (MRI) is gaining interest for brain tissue perfusion studies.
- Current methods often rely on nuclear-medical techniques.
Purpose of the Study:
- To implement an efficient algorithm for quantitative regional cerebral blood volume (rCBV) calculation.
- To enable the use of MRI-based perfusion assessment in clinical routine.
- To provide a tool for evaluating brain perfusion alterations.
Main Methods:
- Utilized the indicator-dilution method following bolus injection of a contrast agent.
- Developed an efficient computational algorithm for rCBV quantification.
- Results are presented as parameter images for visual and quantitative analysis.
Main Results:
- The implemented algorithm efficiently calculates regional cerebral blood volume (rCBV).
- Computation time is approximately 1 minute on a Macintosh Quadra 660AV.
- Generated parameter images allow for global visual inspection and local quantitative evaluation.
Conclusions:
- The developed algorithm offers an efficient method for quantitative rCBV assessment using MRI.
- This technique supports the integration of functional perfusion data into clinical brain assessment.
- Parameter images facilitate comprehensive evaluation of regional cerebral blood flow.