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Related Experiment Videos

Inflammation in benign prostatic hyperplasia: correlation with prostate specific antigen value

J Irani1, P Levillain, J M Goujon

  • 1Department of Urology, Centre Hospitalier Universitaire La Miletrie, Poitiers, France.

The Journal of Urology
|April 1, 1997
PubMed
Summary
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Prostate inflammation aggressiveness, not just density, correlates with serum prostate specific antigen (PSA). Glandular epithelial disruption is key for this association, impacting PSA interpretation in biopsies.

Area of Science:

  • Urology
  • Pathology
  • Oncology

Background:

  • Prostate specific antigen (PSA) is a key biomarker for prostate cancer screening.
  • Benign prostatic hyperplasia (BPH) and inflammation can affect PSA levels.
  • Understanding the relationship between prostatic inflammation morphology and PSA is crucial for accurate diagnosis.

Purpose of the Study:

  • To determine if morphological parameters of benign prostatic hyperplastic inflammation correlate with pre-biopsy prostate specific antigen (PSA) concentrations.
  • To investigate the relationship between inflammation grading, aggressiveness, and serum/urinary PSA levels.

Main Methods:

  • Prospective study of 66 patients undergoing prostate biopsy with exclusively benign prostatic tissue.
  • Morphological grading of inflammation (0-3) and aggressiveness (0-3) in biopsy samples.

Related Experiment Videos

  • Measurement of serum and 24-hour urine PSA levels pre-biopsy.

    • Main Results:

    • No significant difference in serum or urinary PSA between inflammation graded groups.
    • A significant positive correlation was found between aggressiveness grading and serum PSA (rho = 0.51, p < 0.0001).
    • No significant correlation was observed between aggressiveness grading and urinary PSA (rho = -0.06, p = 0.6).

    Conclusions:

    • Subclinical prostatic inflammation alone is not associated with elevated urinary PSA.
    • Prostatic interstitial inflammatory cell infiltrate density does not significantly correlate with serum PSA unless glandular epithelial disruption is present.
    • These findings suggest that the degree of glandular damage due to inflammation, rather than inflammation density alone, is important when interpreting prostate biopsies and PSA levels.