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Apolipoprotein E e4 allele frequency in patients with multiple system atrophy

N J Cairns1, P F Atkinson, T Kovács

  • 1Brain Bank, Department of Neuropathology, Institute of Psychiatry, London, UK. n.cairns@iop.bpmf.ac.uk

Neuroscience Letters
|January 17, 1997
PubMed
Summary

Apolipoprotein E (APOE) e4 allele is not a risk factor for multiple system atrophy (MSA), a neurodegenerative disease. APOE e4 allele frequency was similar in MSA patients and healthy controls, unlike in Alzheimer's disease.

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Area of Science:

  • Neuroscience
  • Genetics
  • Neuropathology

Background:

  • Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by glial cytoplasmic inclusions.
  • Apolipoprotein E (APOE) genotype is a known risk factor for Alzheimer's disease.

Purpose of the Study:

  • To investigate the association between Apolipoprotein E (APOE) genotype and multiple system atrophy (MSA).
  • To determine if the APOE e4 allele is a risk factor for MSA.

Main Methods:

  • DNA was extracted from frozen brain tissue of 22 MSA patients.
  • Polymerase chain reaction and restriction digestion were used to determine APOE genotype.
  • APOE genotype data from 36 Alzheimer's disease patients and 66 healthy controls were used for comparison.

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Main Results:

  • APOE e4 allele frequency in MSA cases (0.11) was not significantly different from control subjects (0.12).
  • APOE e4 allele frequency was significantly increased in Alzheimer's disease subjects (0.44, P < 0.001).

Conclusions:

  • The APOE e4 allele is not a risk factor for multiple system atrophy.
  • These findings differentiate the genetic risk factors for MSA and Alzheimer's disease.