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Aggressive thyroid carcinoma with predominant cribriform growth pattern. Case report
L A Akslen1, B O Maehle, J E Varhaug
1Department of Pathology, Gade Institute, Bergen, Norway.
Pathology, Research and Practice
|November 1, 1996
Summary
This study describes a rare thyroid carcinoma in a 77-year-old male exhibiting aggressive features and a cribriform growth pattern. Further research is needed to determine if this pattern indicates a poorer prognosis in thyroid cancer.
Area of Science:
- Oncology
- Pathology
Background:
- Thyroid carcinomas present a spectrum from differentiated to undifferentiated (anaplastic) types.
- Poorly differentiated thyroid carcinomas often show solid structures and aggressive behavior.
Observation:
- A unique thyroid carcinoma case in a 77-year-old male is presented.
- The tumor displayed a cribriform growth pattern with significant apoptosis, nuclear pleomorphism, high mitotic activity, necrosis, and vascular invasion.
Findings:
- The observed features suggest a poorly differentiated thyroid carcinoma.
- Metastatic spread to lymph nodes and lungs was evident at diagnosis.
- The patient succumbed to the disease 15 months post-diagnosis due to progressive illness.
Implications:
- The cribriform structure in thyroid carcinoma warrants further investigation.
- This pattern may represent an independent indicator of aggressive clinical behavior and a poor prognosis in thyroid cancer patients.