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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[Pneumococcal infections in patients with HIV infections]
1Service des Maladies infectieuses, Hôpital Saint-Louis, Paris.
Unlabelled:
VERY HIGH INCIDENCE: Streptococcus pneumoniae is the most frequent causal agent of bacterial pneumonia in HIV-positive patients. SPECIFIC COURSE: Clinical manifestations are similar to those in normal hosts except for increased rates of bacteremia and recurrent disease, but mortality from pneumococcal disease is substantial in patients with AIDS.
Therapeutic Management:
Although the independent influence of HIV infection has not been well assessed, antibiotics effective against penicillin-resistant strains such as the amoxicillin-clavulanic acid combination or cephalosporines (cefatoxime, ceftriaxone) must be considered in the empirical treatment of HIV-infected patients with pneumococcal disease.
Prophylaxis:
Since the effectiveness of pneumococcal vaccine has not been demonstrated, clinical trials of vaccination performed early in the course of HIV infection are warranted.
Insights
Streptococcus pneumoniae causes frequent bacterial pneumonia in HIV-positive individuals, leading to substantial mortality. Early clinical trials of pneumococcal vaccination in HIV infection are warranted.
Area of Science:
- Infectious Diseases
- Immunology
- Public Health
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