[Effects of histidine on gastric secretory function]

Effect of histidine on secretory activity of the stomach in the dogs was studied. Parenteral administered histidine caused great increase in gastric secretion stipulated by central action and mediated through histamine receptors. Histidine administered per os together with meat increased gastric secretion in some dog but in the other ones the response was absent. In dogs with stimulated gastric secretion the increase in histamine contents in gastric juice was found. Particular effect of histidine on gastric secretion should be taken into account when creating of amino acid mixtures for parenteral nutrition and in dietetics.