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Updated: Aug 12, 2026

Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo
Published on: May 9, 2016
A method for determination of stiffness of collagen molecules
Z P Luo1, M E Bolander, K N An
1Division of Orthopedic Research, Mayo Clinic/Mayo Foundation, Rochester, Minnesota 55905, USA.
Abstract:
This study developed a micromechanical test method for determination of stiffness of collagen molecules. The novelty includes the adoption of an optical tweezer system for loading a single collagen molecule and the development of a binding technique for gripping the collagen molecule termini for the micromechanical test. This methodology will potentially help us to understand the mechanical properties and functions of collagen ultrastructure.
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