Related Experiment Video
Updated: Aug 15, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
Genetic susceptibility for breast cancer: testing and primary prevention options
1Breast Surgical Oncology Service, Memorial Sloan-Kettering Cancer Center in New York, NY, USA.
Purpose/Objectives:
To provide an update on the breast cancer genes BRCA1 and BRCA2 and to review available primary preventive options.
Data Sources:
Published articles, abstracts, and clinical experience.
Data Synthesis:
While genetic testing will help identify a cadre of women at high risk for breast cancer development, it also will raise many psychosocial and ethical issues, including if and when to be tested and what patients and healthcare professional should do with the information.
Conclusions:
The only currently available putative form of primary prevention is prophylactic mastectomy. Diet and the use of tamoxifen remain areas for future research.
Implications For Nursing Practice:
Nurses can play an important role in educating patients who face difficult decisions surrounding genetic testing and primary prevention modalities. Nurses also can design and conduct much needed research in these areas.
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