Related Experiment Video
Updated: Jul 11, 2026
06:27
A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice
Published on: July 20, 2022
A method for assessing catheter patency in implanted pumps for long-term intraperitoneal insulin delivery
M Scavini1, B Hammarberg, F Dosio
1Department of Medicine, Istituto Scientifico H San Raffaele, Milano, Italy.
Artificial Organs
|May 1, 1997
Summary
Technetium-99m imaging can assess intraperitoneal insulin pump catheters for type I diabetes. This method helps identify catheter blockages and impaired insulin delivery, improving long-term therapy management.
Area of Science:
- Nuclear Medicine
- Biomedical Engineering
- Endocrinology
Background:
- Catheter complications are frequent in long-term insulin pump therapy for diabetes.
- Implanted insulin pumps require reliable catheter function for effective treatment.
Purpose of the Study:
- To evaluate the feasibility of using technetium (Tc) 99m imaging for intraperitoneal catheters in insulin delivery devices.
- To determine if Tc 99m can visualize catheter patency and detect complications.
Main Methods:
- An insulin/Tc 99m mixture was tested for physical stability.
- Tc 99m was injected into intraperitoneal insulin pump catheters in patients with type I diabetes.
- Gamma camera imaging was performed to visualize tracer distribution.
Main Results:
- The insulin/Tc 99m mixture showed no aggregation over 48 hours.
- Patent catheters visualized the entire catheter length with Tc 99m.
- Occluded catheters showed tracer confined to the flush port.
- Impaired insulin absorption cases showed delayed tracer removal from the peritoneum.
Conclusions:
- Technetium (Tc) 99m imaging is a feasible method for assessing intraperitoneal insulin delivery catheters.
- This imaging technique can effectively evaluate catheter patency and detect impaired insulin delivery.
- Tc 99m imaging offers a valuable tool for managing complications in long-term insulin pump therapy.
