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Updated: Jul 11, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
Published on: August 15, 2017
Effects of flunarizine and nitrendipine on electroconvulsive shock- and clonidine-induced amnesia
M Genkova-Papazova1, B P Petkova, M Lazarova-Bakarova
1Laboratory of Pharmacology of the CNS, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Abstract:
This study was designed to examine the calcium channel blockers flunarizine and nitrendipine for their ability to prevent electroconvulsive shock (ECS)- or clonidine-induced deterioration of the inhibitory avoidance performance (step-down) in rats. Flunarizine (10 mg/kg) and nitrendipine (40 mg/kg) were found to prevent the ECS- or clonidine-provoked amnesia after oral administration for 12 days. The mechanisms of action of the two drugs are considered. The results of this study further suggest that calcium antagonists might be useful in the treatment of cognitive disorders.
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