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A peptide from the submandibular glands modulates inflammatory responses
R D Mathison1, J S Davison, A D Befus
1Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Canada.
International Archives of Allergy and Immunology
|May 1, 1997
Summary
Submandibular gland peptide T (SGP-T) is an immunoregulatory heptapeptide that reduces inflammation. SGP-T demonstrates anti-inflammatory properties by mitigating hypotension and neutrophil influx.
Area of Science:
- Immunology
- Neuroendocrinology
- Gastroenterology
Background:
- The cervical sympathetic trunk-submandibular gland (CST-SMG) axis is crucial in regulating inflammatory processes.
- Submandibular gland peptide T (SGP-T), an immunoregulatory heptapeptide, has been isolated from submandibular glands.
Purpose of the Study:
- To investigate the biological activities of SGP-T.
- To understand the role of SGP-T in the anti-inflammatory function of the CST-SMG axis.
Main Methods:
- Isolation of SGP-T from submandibular glands.
- Assessment of SGP-T's effects on shock-induced hypotension.
- Evaluation of SGP-T's impact on allergen-induced disruption of myoelectric complexes.
- Measurement of SGP-T's effect on smooth muscle contraction.
- Analysis of SGP-T's inhibition of neutrophil influx into carrageenin-soaked sponges.
Main Results:
- SGP-T significantly reduced shock-induced hypotension.
- The heptapeptide mitigated allergen-induced disruption of migrating myoelectric complexes.
- SGP-T decreased the magnitude of smooth muscle contraction.
- SGP-T inhibited neutrophil influx into inflammatory sponges.
Conclusions:
- SGP-T exhibits multiple biological activities that contribute to the anti-inflammatory capacity of the CST-SMG axis.
- These findings elucidate the mechanisms by which SGP-T modulates inflammation.