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Methapyrilene toxicity

C L Winek, F W Fochtman, W J Trogus

    Clinical Toxicology
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Methapyrilene overdose can be fatal, with deaths occurring at blood levels as low as 2.7 mg%. Concurrent use of other drugs increases the risk of severe outcomes from methapyrilene toxicity.

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    Area of Science:

    • Toxicology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Methapyrilene is an antihistamine with historical use in over-the-counter sleep aids.
    • Understanding the toxicological profile of methapyrilene is crucial for clinical management of overdose cases.

    Observation:

    • This report details seven cases of methapyrilene overdosage, with five resulting in fatalities.
    • Observed methapyrilene blood levels in fatal cases ranged from 1.2 to 3.0 mg%.

    Findings:

    • Five of the seven cases involved co-ingestion of methapyrilene with other substances, including ethanol, salicylamide, amobarbital, secobarbital, and scopolamine.
    • A fatality occurred with methapyrilene alone at a blood level of 2.7 mg%.
    • In a surviving case, significant methapyrilene was removed via serial lavage after ingestion of 2.5 gm, with subsequent low quantifiable blood levels.

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    Implications:

    • These findings highlight the potentially lethal toxicity of methapyrilene, particularly in cases of multiple drug ingestion.
    • Clinical protocols for managing methapyrilene overdose should consider aggressive decontamination methods like gastric lavage.
    • Further research into the synergistic toxic effects of methapyrilene with other common pharmaceuticals is warranted.