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Oncocytic meningioma

F Roncaroli1, L Riccioni, M Cerati

  • 1Department of Clinical Radiology and Anatomic Pathology, University of Bologna, Italy.

The American Journal of Surgical Pathology
|April 1, 1997
PubMed
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Oncocytic meningiomas, a rare tumor type, exhibit aggressive behavior with high recurrence and brain invasion rates. These findings highlight the need for careful monitoring and management of patients with this specific meningioma subtype.

Area of Science:

  • Neurosurgery
  • Pathology
  • Oncology

Background:

  • Meningiomas are tumors arising from the meninges.
  • Oncocytic changes represent a specific cellular morphology within tumors.
  • The clinical and pathological characteristics of oncocytic meningiomas require further elucidation.

Purpose of the Study:

  • To describe the clinicopathological features of six oncocytic meningioma cases.
  • To investigate the aggressive behavior and potential for recurrence in oncocytic meningiomas.
  • To confirm oncocytic differentiation using multiple analytical methods.

Main Methods:

  • Histopathological examination of tumor tissues.
  • Immunocytochemistry to identify specific cellular markers.
  • Electron microscopy for ultrastructural analysis.

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  • Western-blot analysis to assess protein expression.

    • Main Results:

    • Six cases of meningioma with oncocytic features were identified.
    • Tumors consisted of large polygonal cells with eosinophilic, mitochondrion-rich cytoplasm.
    • Nuclear pleomorphism, necrosis, and high mitotic rates were common.
    • Oncocytic differentiation was confirmed by histology, immunocytochemistry, electron microscopy, and Western-blot.
    • Aggressive behavior was noted, with three recurrences and two cases of brain invasion.

    Conclusions:

    • Oncocytic meningiomas represent a distinct subtype with aggressive clinical behavior.
    • The presence of oncocytic changes is associated with a higher risk of recurrence and invasion.
    • Further research is warranted to understand the molecular mechanisms driving the aggressiveness of oncocytic meningiomas.