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Pulmonary lavage in patients treated with mechanical ventilation
Chest
|November 1, 1977
Summary
Pulmonary lavage using saline solution effectively improved oxygenation and lung compliance in patients with respiratory failure. This procedure offers a beneficial therapeutic option for selected individuals struggling with mucous plugs and secretions.
Area of Science:
- Pulmonary Medicine
- Critical Care Medicine
Background:
- Mucous plugs and secretions in small airways can impair gas exchange and lung compliance.
- Conventional therapies are often inadequate for removing these secretions, particularly in mechanically ventilated patients.
Purpose of the Study:
- To evaluate the therapeutic benefits of pulmonary lavage on oxygenation and compliance in patients with respiratory failure.
Main Methods:
- Pulmonary lavage was performed using physiologic saline solution (237 +/- 6 ml) via flexible fiberoptic bronchoscope.
- The procedure was conducted on 43 occasions in patients experiencing respiratory failure.
Main Results:
- Significant improvement in the ratio of arterial to alveolar oxygen pressures (PaO2/PAO2) was observed in 81% of lavages within 11 hours.
- Effective static compliance (Cst) significantly increased in 63% of lavages within 8 hours.
- Transient decreases in PaO2/PAO2 and Cst were noted immediately post-lavage, with no persistent complications.
Conclusions:
- Pulmonary lavage is a useful therapeutic method for selected patients with respiratory failure.
- The procedure demonstrates significant benefits in improving oxygenation and lung compliance.