Evaluation of cold areas on the thyroid scan with 99mTc solcocitran

Cold areas on a 99mTc pertechnetate thyroid scan were reevaluated using 99mTc Solcocitran in 31 patients. In 27 patients surgical specimens were obtained for histologic studies. Of 20 benign lesions, five showed a relatively increased uptake of 99mTc Solcocitran. Two of seven malignant lesions were interpreted as positive on the 99mTc Solcocitran scan. This study indicates that 99mTc Solcocitran is not a valuable radiopharmaceutical for differentiating cold areas.