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Related Experiment Videos

[Cancer-associated retinopathy]

H Ohguro1, T Takaya, K Ogawa

  • 1Department of Ophthalmology, Sapporo Medical University School of Medicine, Hokkaido, Japan.

Nippon Ganka Gakkai Zasshi
|April 1, 1997
PubMed
Summary

Paraneoplastic retinopathy, including cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR), involves autoimmune responses targeting the eye. These conditions can manifest before cancer diagnosis, affecting vision through retinal degeneration or bipolar cell dysfunction.

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Retinal dysfunction in cancer-associated retinopathy is improved by Ca(2+) antagonist administration and dark adaptation.

Investigative ophthalmology & visual science·2001
Same author

[Autoimmune mechanisms in molecular pathology of glaucomatous optic neuropathy].

Nippon Ganka Gakkai zasshi·2001
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[Carcinoma-associated retinopathy].

Ryoikibetsu shokogun shirizu·2001
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Mechanisms of photoreceptor cell death in cancer-associated retinopathy.

Investigative ophthalmology & visual science·2001
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[Molecular mechanism of cancer-associated retinopathy and tumor antigens].

Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology·2001
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Identification of human antitumor cytotoxic T lymphocytes epitopes of recoverin, a cancer-associated retinopathy antigen, possibly related with a better prognosis in a paraneoplastic syndrome.

European journal of immunology·2001

Area of Science:

  • Ophthalmology
  • Oncology
  • Immunology

Context:

  • Paraneoplastic syndromes can affect the central nervous system, including the eyes.
  • Two primary retinopathy types are associated with malignancies: cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR).

Purpose:

  • To differentiate between cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR).
  • To describe the clinical and immunological characteristics of CAR and MAR.

Summary:

  • Cancer-associated retinopathy (CAR) is linked to epithelial cancers, presenting as retinitis pigmentosa-like degeneration, often diagnosed before the primary cancer.
  • Melanoma-associated retinopathy (MAR) is associated with cutaneous malignant melanoma, characterized by sudden photophobia and nyctalopsia, with electroretinogram (ERG) abnormalities suggesting bipolar cell involvement.

Related Experiment Videos

  • Both CAR and MAR are presumed autoimmune conditions. CAR involves antibodies against recoverin and neurofilaments, while MAR antigens remain unidentified but target retinal bipolar cells.

    • Impact:

    • Understanding the distinct features of CAR and MAR aids in their diagnosis and management.
    • Identifying these paraneoplastic retinopathies can lead to earlier cancer detection.
    • Further research into MAR antigens may reveal new diagnostic markers and therapeutic targets.