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Three-dimensional cortical morphometry of the planum temporale in childhood-onset schizophrenia
L K Jacobsen1, J N Giedd, C Tanrikut
1Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA. lkj@helix.nih.gov
Objective:
Anomalous planum temporale asymmetry has been linked to both schizophrenia and dyslexia. The authors examined the planum temporale of adolescents with childhood-onset schizophrenia who had a high rate of prepsychotic language disorders.
Method:
Planum temporale area and asymmetry were measured in 16 right-handed adolescent patients with schizophrenia who had experienced onset of psychosis by age 12. The same measures were made in 16 healthy adolescents matched for age, sex, and handedness.
Results:
No differences between the healthy adolescents and those with schizophrenia in planum temporale area or asymmetry were observed. Prepsychotic language disorder predicted abnormal planum temporale asymmetry in the adolescents with schizophrenia.
Conclusions:
These findings do not support anomalous planum temporale asymmetry as a basis for psychopathology in childhood-onset schizophrenia.