Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic lymphocytic leukemia

G Dighiero1, J L Binet

  • 1Institut Pasteur, Unité d'Immuno Hématologie et d'Immuno Pathologie, Paris, France.

Hematology and Cell Therapy
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monoclonal and/or Oligoclonal Immunoglobulins in Sera of Patients with Non-Hodgkin's Lymphomas, Determined by Iso-Electric Focusing and Immunoblotting.

Leukemia & lymphoma·2016
Same author

B Cell Malignancies Frequently Target the Autoreactive B Cell Repertoire.

Leukemia & lymphoma·2016
Same author

Proposals for a Phenotypic Classification of B-Chronic Lymphocytic Leukemia, Relationship with Prognostic Factors.

Leukemia & lymphoma·2016
Same author

Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation.

Leukemia·2014
Same author

"Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia''.

Blood cancer journal·2013
Same author

Lipoprotein lipase expression in unmutated CLL patients is the consequence of a demethylation process induced by the microenvironment.

Leukemia·2012
Same journal

The place of instruments in the scientific work of Marcel Bessis (1917-1994): the electron microscope and the ektacytometer.

Hematology and cell therapy·2001
Same journal

In memory of Marcel Bessis.

Hematology and cell therapy·2001
Same journal

Emerging therapies and future directions in CLL--monoclonal antibodies, vaccines and gene therapy.

Hematology and cell therapy·2000
Same journal

Emerging therapies and future directions in chronic lymphocytic leukaemia--chemotherapy.

Hematology and cell therapy·2000
Same journal

Chronic lymphocytic leukemia . Clinical oral poster session.

Hematology and cell therapy·2000
Same journal

Current therapy for CLL.

Hematology and cell therapy·2000
See all related articles

B-cell chronic lymphocytic leukemia (B-CLL) involves the accumulation of non-functional lymphocytes. These leukemia cells resist transformation and exhibit specific surface markers and genetic traits.

Area of Science:

  • Hematology
  • Oncology

Background:

  • B-cell chronic lymphocytic leukemia (B-CLL) is a prevalent leukemia in Western countries.
  • It is characterized by the accumulation of long-lived, functionally incompetent mature lymphocytes.

Purpose of the Study:

  • To describe the key characteristics of B-cell chronic lymphocytic leukemia.
  • To highlight the unique cellular and genetic features of B-CLL.

Main Methods:

  • Analysis of lymphocyte surface markers (immunoglobulin, CD5).
  • Assessment of cellular behavior (resistance to EBV transformation, G0 phase, bcl-2 expression).
  • Review of genetic abnormalities in B-CLL.

Main Results:

  • B-CLL lymphocytes express low surface immunoglobulin and CD5.

Related Experiment Videos

  • These cells are resistant to Epstein Barr Virus transformation and are in a prolonged G0 phase.
  • High bcl-2 expression and defective antigen receptor response are observed.
  • No typical chromosomal aberrations or oncogenic abnormalities are associated with B-CLL.

    • Conclusions:

    • B-CLL is defined by a distinct profile of lymphocyte dysfunction and specific molecular markers.
    • The disease lacks characteristic genetic aberrations, differentiating it from other leukemias.