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[Diagnosis of cirrhosis in adults]
1Service d'hépatogastro-entérologie Hôpital Jean-Verdier, Bondy.
Insights
Cirrhosis diagnosis requires liver biopsy for histological analysis, aiding in identifying causes and severity. Clinical signs can suggest cirrhosis without biopsy, especially with hepatic failure or portal hypertension.
Area of Science:
- Hepatology
- Gastroenterology
- Pathology
Context:
- Liver biopsy is the gold standard for diagnosing cirrhosis.
- Transparietal and transjugular routes are common biopsy methods.
- Histological analysis characterizes disease cause and severity.
Purpose:
- To outline the diagnostic process for cirrhosis.
- To detail the role of liver biopsy in cirrhosis assessment.
- To identify common causes of cirrhosis.
Summary:
- Diagnosis of cirrhosis relies on liver biopsy for histological analysis.
- Histology helps determine the causative process and disease severity.
- Clinical findings like a firm liver with a narrow edge can indicate cirrhosis in the absence of biopsy.
Impact:
- Informs clinical practice for cirrhosis diagnosis.
- Highlights the importance of histological confirmation.
- Provides insight into the prevalence of cirrhosis causes, including rising viral infections.
Abstract:
The diagnosis of cirrhosis relies on the histological analysis of a liver sample provided by biopsy made by transparietal or transjugular route according to the haemostasis of the patient. The histological study allows also to characterize the causative process and the severity of the disease. In the absence of histological proof a high probability of cirrhosis could be assumed when a firm liver with a narrow inferior edge is associated or not with signs of hepatic failure or portal hypertension. The most common causes of cirrhosis in France are alcohol abuse, C and B viruses, genetic haemochromatosis, chronic active autoimmune hepatitis, primary biliary cirrhosis. The prevalence of viral causes is increasing.