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Related Experiment Videos

Spatial memory in transgenic mice with impaired glucocorticoid receptor function

I Rousse1, S Beaulieu, W Rowe

  • 1Douglas Hospital Research Center, Department of Psychiatry, McGill University, Verdun, Quebec, Canada.

Neuroreport
|March 3, 1997
PubMed
Summary

Transgenic mice with impaired glucocorticoid receptor function showed deficits in spatial learning and memory. Their non-optimal behavioral strategies in maze tasks contributed to this impaired performance.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Molecular Biology

Background:

  • Glucocorticoid receptors play a crucial role in cognitive functions, including spatial learning and memory.
  • Understanding the impact of impaired glucocorticoid receptor function is vital for cognitive research.

Purpose of the Study:

  • To assess the spatial learning and memory capabilities of transgenic mice with impaired glucocorticoid receptor function.
  • To investigate the behavioral strategies employed by these mice in complex maze tasks.

Main Methods:

  • Utilized the Morris water maze and the radial arm maze to evaluate spatial learning and memory.
  • Compared the performance of transgenic mice to their parent strain (B6C/3F1).

Main Results:

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  • Transgenic mice exhibited longer latencies to find platforms in the Morris water maze compared to controls.
  • Transgenic mice made significantly more errors in the radial arm maze.
  • Altered, non-optimal behavioral strategies were observed in transgenic mice during both tasks.

Conclusions:

  • Impaired glucocorticoid receptor function in transgenic mice leads to deficits in spatial learning and memory.
  • Altered behavioral strategies are a key factor contributing to the cognitive impairments observed in these mice.