Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular development: cellular and molecular regulation

L Beck1, P A D'Amore

  • 1Department of Pathology, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study of radiation damage of 28 MeV protons to the Lassena Monolithic Active Pixel Sensor.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2025
Same author

Altered placental macrophage numbers and subsets in pregnancies complicated with intrahepatic cholestasis of pregnancy (ICP) compared to healthy pregnancies.

Placenta·2024
Same author

Studies of Charm Quark Diffusion inside Jets Using Pb-Pb and pp Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2020
Same author

Search for heavy resonances that decay into a vector boson and a Higgs boson in hadronic final states at <math> </math> <math></math>.

The European physical journal. C, Particles and fields·2020
Same author

Search for physics beyond the standard model in events with two leptons of same sign, missing transverse momentum, and jets in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2020
Same author

Search for new phenomena with the <math></math> variable in the all-hadronic final state produced in proton-proton collisions at <math> </math> <math></math>.

The European physical journal. C, Particles and fields·2020
Same journal

Sinomenine Regulates the TRIM32/IRF1/TRAF6 Axis to Inhibit Pyroptosis in Atopic Dermatitis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Urolithin A Mitigates Renal Fibrosis by Promoting Fatty Acid Oxidation Through Orchestrating β-Catenin Signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

MiR-124 Inhibits Lipid Deposition in Mouse Liver by Targeting the Trib3/Hnf4α Pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

TCN2 Drives Psoriasis-Like Inflammation and Keratinocyte Hyperproliferation, Correlating With IL-1β and STAT3 Activation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

The Synthetic Melanocortin Agonist NDP-MSH Ameliorates THSD7A-Associated Membranous Nephropathy in an Active Immunization Mouse Model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Brain-Derived Neurotrophic Factor and Associated Signaling in Kidney Diseases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
See all related articles

Vascular system development involves vasculogenesis and angiogenesis, regulated by growth factors and cell interactions. These processes orchestrate vessel formation for the adult circulatory system.

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Cell Biology

Background:

  • The vascular system develops through two primary mechanisms: vasculogenesis (de novo vessel formation) and angiogenesis (new vessel growth from existing ones).
  • While distinct, these processes share regulatory pathways.
  • Recent advancements in growth factor identification, genetic manipulation models, and cell-cell interaction studies have significantly improved our understanding of vascularization.

Purpose of the Study:

  • To elucidate the complex regulatory mechanisms governing vascular system development.
  • To highlight the roles of specific growth factors and cell interactions in vasculogenesis and angiogenesis.

Main Methods:

  • Review of current literature on vascular development.
  • Analysis of findings from genetically manipulated mouse models.

Related Experiment Videos

  • Examination of the impact of various growth factors and cell-cell interactions.

    • Main Results:

    • Identified key polypeptide growth factors, including platelet-derived growth factor, vascular endothelial growth factor, transforming growth factor-beta, and angiopoietins, orchestrate vascular development.
    • Demonstrated that cell-cell interactions within the vascular wall and communication between the vasculature and surrounding tissues are crucial.
    • Highlighted shared regulatory mechanisms between vasculogenesis and angiogenesis.

    Conclusions:

    • Vascular development is a highly orchestrated process involving a complex interplay of growth factors and cellular interactions.
    • Effective communication between forming vessels and tissue parenchyma, alongside intra-vascular cell signaling, is essential for proper vascular growth and development.