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Blood volume determination using hydroxyethyl starch: a rapid and simple intravenous injection method
K Tschaikowsky1, M Meisner, R Durst
1Department of Anesthesiology, University of Erlangen-Nürnberg, Germany.
Critical Care Medicine
|April 1, 1997
Summary
A new method using hydroxyethyl starch accurately measures blood volume. This rapid technique shows high correlation with conventional methods, potentially improving perioperative fluid management.
Area of Science:
- Biomedical Engineering
- Clinical Chemistry
Background:
- Accurate blood volume measurement is crucial for effective perioperative fluid and blood therapy.
- Existing methods for blood volume determination can be time-consuming or invasive.
Purpose of the Study:
- To develop and validate a novel method for blood volume measurement using hydroxyethyl starch as a dilution marker.
- To assess the accuracy and reliability of the hydroxyethyl starch method compared to a conventional technique.
Main Methods:
- Laboratory and clinical investigation involving 12 neurosurgical patients and 50 volunteers.
- Intravenous injection of hydroxyethyl starch and simultaneous carbon monoxide administration.
- Analysis of blood samples for carboxyhemoglobin and glucose concentrations to calculate blood volume.
Main Results:
- The hydroxyethyl starch method demonstrated high in vitro accuracy (approx. 2% error and precision).
- In vivo validation showed a strong correlation (r² = .96, p < .001) with the carbon monoxide method.
- Mean difference between methods was 1.0 +/- 3.5%, with a bias of 52.3 mL.
Conclusions:
- Blood volume determination using the hydroxyethyl starch method is accurate and rapid.
- This new method has the potential to enhance perioperative monitoring of fluid and blood therapy.