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Related Experiment Videos

Human skeletal muscle protein breakdown during spaceflight

T P Stein1, M D Schluter

  • 1Department of Surgery, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford 08084, USA.

The American Journal of Physiology
|April 1, 1997
PubMed
Summary

Human spaceflight and bed rest studies show that myofibrillar protein breakdown, measured by 3-methylhistidine (3-MH) excretion, is not increased. Muscle protein breakdown is not an inevitable consequence of spaceflight.

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Area of Science:

  • Space physiology
  • Human physiology
  • Biochemistry

Background:

  • Human spaceflight is linked to body protein loss.
  • 3-methylhistidine (3-MH) in urine measures myofibrillar protein breakdown.
  • Head-down tilt bed rest simulates spaceflight conditions.

Purpose of the Study:

  • Compare 3-MH excretion during shuttle missions and bed rest.
  • Investigate muscle protein breakdown in simulated and actual spaceflight.
  • Determine if muscle protein breakdown is an inevitable outcome of spaceflight.

Main Methods:

  • Collected urine samples from astronauts (n=9) on two shuttle missions (9.5 and 15 days).
  • Collected urine samples from participants (n=7) during 17 days of 6-degree head-down tilt bed rest.
Keywords:
NASA Discipline MusculoskeletalNon-NASA Center

Related Experiment Videos

  • Measured nitrogen and 3-methylhistidine (3-MH) excretion in urine samples.

    • Main Results:

    • Nitrogen retention decreased significantly during both bed rest and spaceflight.
    • Urinary 3-MH excretion remained unchanged during bed rest.
    • Urinary 3-MH excretion did not change significantly during spaceflight.

    Conclusions:

    • 3-MH excretion was not affected by shuttle spaceflight or bed rest.
    • Muscle protein breakdown is not a guaranteed consequence of spaceflight, unlike findings from Skylab missions.