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Naturally occurring primary deficiencies of the immune system
A Fischer1, M Cavazzana-Calvo, G De Saint Basile
1Unité INSERM U 429, Hôpital Necker-Enfants Malades, Paris, France.
Annual Review of Immunology
|January 1, 1997
Abstract:
Naturally occurring genetic disorders of the immune system provide many models for the study of its development and function. In a way, their analysis complements the information provided by the generation of genetic defects in mice created using homologous recombination techniques. In this review, the recent findings made in three areas are focused upon deficiencies in T cell differentiation and in T lymphocyte activation, and on the control process of peripheral immune response.