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Digitalis effect and blood concentration

J Schneider, A Ruiz-Torres

    International Journal of Clinical Pharmacology and Biopharmacy
    |September 1, 1977
    PubMed
    Summary
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    This study establishes the therapeutic range for digitalis glycosides in heart failure patients. Digoxin blood concentrations above 2.0 ng/ml indicate a clear risk of intoxication.

    Area of Science:

    • Cardiology
    • Clinical Pharmacology

    Background:

    • Digitalis glycosides are crucial in managing heart failure.
    • Establishing precise therapeutic ranges is vital for patient safety and efficacy.

    Purpose of the Study:

    • To determine the therapeutic range of digitalis glycosides.
    • To correlate cardial and extracardial effects with digoxin blood concentrations.

    Main Methods:

    • Analysis of 1109 digoxin blood concentration determinations.
    • Inclusion of data from 317 patients diagnosed with heart failure.

    Main Results:

    • The therapeutic range for digitalis glycosides was established.
    • A clear limit for digoxin intoxication was identified at concentrations above 2.0 ng/ml.

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    Conclusions:

    • The study provides critical data for optimizing digitalis therapy in heart failure.
    • Monitoring digoxin levels is essential to avoid toxicity and ensure therapeutic benefit.