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Specific protein recognition of an mRNA cap through its alkylated base

A E Hodel, P D Gershon, X Shi

Nature Structural Biology

|May 1, 1997

Abstract:

The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.

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