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Multiple antibiotic resistance in Stenotrophomonas maltophilia
1Banco de Células, Centro Nacional de Biotecnología (CSIC), Campus UAM, Cantoblanco, Madrid, Spain.
Antimicrobial Agents and Chemotherapy
|May 1, 1997
Abstract:
A cryptic multidrug resistance (MDR) system in Stenotrophomonas maltophilia, the expression of which is selectable by tetracycline, is described. Tetracycline resistance was the consequence of active efflux of the antibiotic, and it was associated with resistance to quinolones and chloramphenicol, but not to aminoglycosides or beta-lactam antibiotics. MDR is linked to the expression of an outer membrane protein (OMP54) both in a model system and in multidrug-resistant clinical isolates.