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Genetic renal mechanisms of hypertension
1Division of Nephrology, Dialysis and Hypertension and Postgraduate School of Nephrology, University of Milano, S. Raffaele Hospital, Italy.
Current Opinion in Nephrology and Hypertension
|March 1, 1997
Abstract:
An update on renal genetic mechanisms of spontaneous hypertension in rats and in human essential hypertension is presented. The findings are discussed, highlighting the search of a possible link between the discovered genetic abnormality and the renal function changes that may determine the disease. The analogies (and/or differences) between the numerous positive findings obtained in animal models and the relatively scarce ones obtained in humans are discussed.