Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD44 expression in the developing human retina

S Nishina1, A Hirakata, T Hida

  • 1Department of Ophthalmology, National Children's Hospital, Tokyo, Japan.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myeloperoxidase-anti-neutrophil cytoplasmic antibody positivity and disease characteristics, treatment, and prognosis in eosinophilic granulomatosis with polyangiitis.

Scandinavian journal of rheumatology·2025
Same author

Nationwide study of surgery for primary infected abdominal aortic and common iliac artery aneurysms.

The British journal of surgery·2021
Same author

Delayed onset of metronidazole-induced encephalopathy in a patient with systemic sclerosis accompanied by intestinal pseudo-obstruction.

Scandinavian journal of rheumatology·2019
Same author

Intraoperative ultrasonic navigation for laparoscopic colorectal surgery with preservation of the left colic artery.

Techniques in coloproctology·2018
Same author

First isolation of West Nile virus in Zambia from mosquitoes.

Transboundary and emerging diseases·2018
Same author

A novel red-emitting K<sub>2</sub>Ca(PO<sub>4</sub>)F:Eu<sup>2+</sup> phosphor with a large Stokes shift.

Chemical communications (Cambridge, England)·2017
Same journal

Association between probiotic prescriptions and the incidence of primary open-angle glaucoma in patients with documented dry eye.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same journal

Clinical outcomes of 577-nm subthreshold micropulse laser therapy in chronic central serous chorioretinopathy: influence of retinal pigment epithelium alterations and baseline OCT characteristics.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same journal

Effect of ablation-zone diameter on whole-corneal higher-order aberrations after LASEK: a retrospective study.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same journal

Real-world comparison of faricimab and aflibercept as second-line therapies for neovascular age-related macular degeneration.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same journal

Retinal imaging for cerebrovascular risk stratification: evidence, limitations, and practical thresholds for the ophthalmologist.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same journal

Layer-by-layer macular, peripapillary retinal nerve fiber layer thickness and minimum rim width changes in PLWH with undetectable viral load: an OCT-based study.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
See all related articles

CD44 expression in the human retina begins late in fetal development, appearing on Müller cells and astrocytes. This molecule is crucial for neural retina development and maintenance throughout life.

Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Neuroscience

Background:

  • CD44, a transmembrane adhesion molecule, is present in the fetal brain and involved in neuroglial interactions.
  • Its role in the developing human retina has not been fully elucidated.

Purpose of the Study:

  • To investigate the expression and distribution of CD44 in the developing human retina.
  • To understand the role of CD44 in retinal development and homeostasis.

Main Methods:

  • Immunohistochemical staining of human retinal tissues from 6 weeks gestation to adulthood using CD44 antibodies.
  • Evaluation of co-expression with vimentin and glial fibrillary acidic protein (GFAP).
  • Light and electron microscopy were employed for detailed analysis.

Related Experiment Videos

Main Results:

  • CD44 expression was first detected at 21 weeks gestation in longitudinal fibers and around capillaries.
  • Co-expression with vimentin and GFAP was observed simultaneously with CD44.
  • Immunoelectron microscopy confirmed CD44 presence on Müller cells and astrocytes, with notable expression in astrocytes in infant and adult retinas.

Conclusions:

  • CD44 is expressed in Müller cells late in fetal development.
  • CD44 is present in fetal, infant, and adult astrocytes.
  • CD44 likely plays a significant role in the morphogenesis and homeostasis of the neural retina.