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[Cardiocirculatory effects of halothane and isoflurane in respiratory distress caused by oleic acid]
M J Cobreces-García1, F J Castañeda-Casado
1Laboratorio Experimental, Cátedra de Anestesiología, Facultad de Medicina de Valladolid.
Introduction:
When lungs are damaged or affected by edema they behave differently from healthy lungs in the presence of drugs that can modify vascular reactivity.
Objectives:
To determine the effects of halothane and isoflurane on pulmonary edema induced by oleic acid in dogs.
Material And Methods:
Eighteen dogs were anesthetized with sodium pentothal. Hemodynamic and lung parameters as well as end-tidal gases were monitored. Pulmonary edema was induced with an injection of oleic acid (0.1 ml/kg). Five periods were studied: 1) before injection of oleic acid; 2) 90 min after injection; 3) 20 min after ventilation with 1 MAC halothane or isoflurane; 4) 20 min after 2 MAC ventilation with the assigned anesthetic, and 5) 20 min after withdrawal of anesthetic.
Results:
With halothane, cardiac output and arterial blood pressure decreased significantly. With isoflurane, arterial pressure decreased by way of changes in vascular resistance. Neither anesthetic affected hypoxic pulmonary vasoconstriction.
Conclusions:
Neither anesthetic worsens arterial oxygenation in a model of pulmonary edema that is similar to adult respiratory distress.