Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rat tyrosine hydroxylase gene polymorphisms

S Murru1, L Pani, D Poddie

  • 1Istituto di Clinica e Biologia dell'Etá Evolutiva, Universitá degli Studi di Cagliari, Italy.

Brain Research. Molecular Brain Research
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Moderate-high heritability and QTL associated with Manila clam Ruditapes philippinarum resistance to the parasite Perkinsus olseni.

BMC genomics·2026
Same author

Interactions between macro- and micro-climate: Effects on phenolic compound production in Nardus stricta at high elevations.

Plant biology (Stuttgart, Germany)·2025
Same author

Effects of seed infection by Fusarium verticillioides on maize performance against Sesamia nonagrioides attack.

Physiologia plantarum·2024
Same author

[Therapeutic mechanism of aqueous extract of <i>Semiliquidambar cathayensis</i> Chang root for pancreatic cancer: the active components, therapeutic targets and pathways].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2024
Same author

A novel approach to myringotomy simulation.

The Journal of laryngology and otology·2022
Same author

Genome-wide association analysis for fumonisin content in maize kernels.

BMC plant biology·2019
Same journal

Adenoviral interneuronal transportation after retrograde gene transfer in mice.

Brain research. Molecular brain research·2005
Same journal

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

Brain research. Molecular brain research·2005
Same journal

Scutellariae radix extracts suppress ethanol-induced caspase-11 expression and cell death in N(2)a cells.

Brain research. Molecular brain research·2005
Same journal

Two estrogen replacement therapies differentially regulate expression of estrogen receptors alpha and beta in the hippocampus and cortex of ovariectomized rat.

Brain research. Molecular brain research·2005
Same journal

Molecular regulation of glutamate and GABA transporter proteins by clobazam during epileptogenesis in Fe(+++)-induced epileptic rats.

Brain research. Molecular brain research·2005
Same journal

Partial cloning of neuronal nitric oxide synthase (nNOS) cDNA and regional distribution of nNOS mRNA in the central nervous system of the Nile tilapia Oreochromis niloticus.

Brain research. Molecular brain research·2005
See all related articles

Researchers identified five DNA polymorphisms in the rat tyrosine hydroxylase gene (TH). This genetic variation is crucial for understanding animal models of affective disorders and addiction behaviors in pharmacogenetic studies.

Area of Science:

  • Genetics
  • Neuroscience
  • Pharmacology

Background:

  • The tyrosine hydroxylase gene (TH) plays a critical role in neurotransmitter synthesis.
  • Understanding genetic variations in TH is essential for studying neurological and behavioral conditions.

Purpose of the Study:

  • To characterize DNA polymorphisms within the rat tyrosine hydroxylase gene (TH).
  • To provide genetic markers for future pharmacogenetic research.

Main Methods:

  • Analysis of the rat TH gene in various rat strains.
  • Utilized Southern blotting and restriction-endonuclease mapping.
  • Sequencing of PCR-amplified DNA products to detect polymorphisms.

Main Results:

  • Identified and characterized five distinct polymorphic sites in the rat TH gene.

Related Experiment Videos

  • Established genetic markers across different rat strains.

    • Conclusions:

    • The identified TH gene polymorphisms offer valuable tools for genetic research.
    • These findings can advance the study of animal models for affective disorders and addiction.