Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pleural tuberculosis

J Ferrer1

  • 1Servei de Pneumologia, Hospital General Universitari Vall d'Hebron, Barcelona, Spain.

The European Respiratory Journal
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Tuberculous pleural effusions are common in tuberculosis patients. Diagnosis involves pleural fluid tests like adenosine deaminase and interferon-gamma, with treatment typically lasting six months.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A phase II, multicenter, open-label, single-arm study of berzosertib plus topotecan in patients with relapsed platinum-resistant small-cell lung cancer (DDRiver SCLC 250).

ESMO open·2025
Same author

Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology.

Nature metabolism·2024
Same author

Metabolic and productive adaptive response of beef cows to successive short-nutritional challenges.

Research in veterinary science·2024
Same author

Correction to: Internet-based interdisciplinary therapeutic group (Grupo Interdisciplinar Online, GIO) for perinatal anxiety and depression-a randomized pilot study during COVID-19.

Archives of women's mental health·2024
Same author

Internet-based interdisciplinary therapeutic group (Grupo Interdisciplinar Online, GIO) for perinatal anxiety and depression-a randomized pilot study during COVID-19.

Archives of women's mental health·2023
Same author

Modelling beef cows' individual response to short nutrient restriction in different lactation stages.

Animal : an international journal of animal bioscience·2022
Same journal

Beyond the 5th percentile: rethinking diagnostic thresholds in pulmonary function testing.

The European respiratory journal·2026
Same journal

A Transcriptomic Atlas of Chronic Lung Allograft Dysfunction.

The European respiratory journal·2026
Same journal

Risk of cancer and mortality in patients with interstitial lung diseases: Danish cohort study.

The European respiratory journal·2026
Same journal

Proposing a minimal important difference in NTproBNP in pulmonary arterial hypertension.

The European respiratory journal·2026
Same journal

Unlocking growth potential: Ivacaftor therapy and developmental gains in lung and height in a cohort study of children and young adults with cystic fibrosis.

The European respiratory journal·2026
Same journal

Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment <i>via</i> Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics.

The European respiratory journal·2026
See all related articles

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Immunology

Background:

  • Tuberculous pleural effusions complicate up to 30% of tuberculosis cases.
  • Human immunodeficiency virus (HIV) status does not significantly alter effusion prevalence, though low CD4+ counts may reduce likelihood.
  • Recent research focuses on the complex immunology of tuberculous pleurisy, involving cytokine production and cellular responses to mycobacteria.

Purpose of the Study:

  • To review the current understanding of tuberculous pleural effusions.
  • To highlight diagnostic advancements and treatment strategies.
  • To discuss the immunological mechanisms underlying the condition.

Main Methods:

  • Review of recent research on tuberculous pleurisy immunology.
  • Analysis of diagnostic markers in pleural fluid.

Related Experiment Videos

  • Evaluation of current treatment guidelines.

    • Main Results:

    • Activated immune cells produce cytokines, leading to intramacrophage elimination, granuloma formation, and fibrosis.
    • Adenosine deaminase and interferon-gamma in pleural fluid are effective diagnostic markers.
    • Mycobacterial DNA detection via polymerase chain reaction shows promise but requires further validation.
    • Standard treatment involves a six-month regimen of isoniazid and rifampicin, potentially longer for HIV patients.

    Conclusions:

    • Tuberculous pleural effusions involve a complex immune response.
    • Diagnostic accuracy is improved by pleural fluid adenosine deaminase and interferon-gamma levels.
    • Standard anti-tuberculosis therapy is effective, with individualized adjustments for HIV-positive individuals.
    • Corticosteroids are generally not recommended but may benefit symptomatic patients.