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Updated: Jan 28, 2026

Plaquing of Herpes Simplex Viruses
Published on: November 5, 2021
Retinal perivasculitis in an immunocompetent patient with systemic herpes simplex infection
D M Chatzoulis1, P G Theodosiadis, M N Apostolopoulos
1Department of Ophthalmology, School of Medicine, Athens University, Greece.
Purpose:
To describe a case of retinal perivasculitis in an immunocompetent patient with systemic herpes simplex infection.
Methods:
Polymerase chain reaction amplifications were performed for aqueous and blood samples using primers specific for the following members of the herpesvirus family: cytomegalovirus, Epstein-Barr virus, herpes simplex virus (types 1 and 2), and varicella-zoster virus. The patient was placed on intravenous acyclovir and systemic corticosteroids.
Results:
A positive polymerase chain reaction signal was found only for herpes simplex virus type 1. Vision in the left eye improved from light perception to 20/25, and signs of retinal perivasculitis resolved.
Conclusion:
The use of molecular diagnostic modalities in clinical practice may aid in determining infectious etiologies in patients with atypical clinical manifestations.
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