Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Allogeneic pregnancy as immunoabsorbent

T G Wegmann, G A Carlson

    Journal of Immunology (Baltimore, Md. : 1950)
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Pregnant mice absorb antibodies against paternal antigens, suggesting a mechanism to protect fetuses from maternal immune rejection. This immune tolerance is crucial for successful pregnancy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Disruptive mood dysregulation disorder at the age of 6 years and clinical and functional outcomes 3 years later.

    Psychological medicine·2016
    Same author

    Personality diatheses and Hurricane Sandy: effects on post-disaster depression.

    Psychological medicine·2015
    Same author

    Fifty years of H-2 research.

    Immunology today·2014
    Same author

    Prospects for vaccinating against pregnancy.

    Immunology today·2014
    Same author

    Immunologic privilege in the eye and the fetus.

    Immunology today·2014
    Same author

    Vasectomy, antibodies to sperm, and atherosclerosis.

    Immunology today·2014

    Area of Science:

    • Immunology
    • Reproductive biology
    • Maternal-fetal interface

    Background:

    • Maternal immune system recognizes paternal antigens during pregnancy.
    • Mechanisms of immune tolerance during pregnancy are not fully understood.
    • Paternal antigen presentation may neutralize maternal immune responses.

    Purpose of the Study:

    • To investigate if allogeneically pregnant females neutralize passively administered anti-paternal antibodies.
    • To explore potential mechanisms of immune tolerance during pregnancy.

    Main Methods:

    • Utilizing two distinct methods to assess antibody absorption in pregnant mice.
    • Comparing antibody absorption in mice with allogeneic pregnancies versus syngeneic or third-party pregnancies.

    Related Experiment Videos

    Main Results:

    • Allogeneically pregnant mice demonstrated rapid absorption of antibodies against paternal strain major histocompatibility (H-2) antigens.
    • Control mice (syngeneic or third-party pregnancies) showed significantly less antibody absorption.
    • This suggests a targeted neutralization of anti-paternal antibodies.

    Conclusions:

    • Pregnant mice actively absorb antibodies targeting paternal antigens, indicating a sophisticated immune tolerance mechanism.
    • This absorption may be a key factor in preventing maternal immune rejection of the fetus.
    • Further research is needed to identify the specific sites of antibody absorption.