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[Multidrug resistance protein (MRP)]

T Abe1, T Mori, S Hori

  • 1Department of Neurosurgery, Oita Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 1, 1997
PubMed
Summary
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Multidrug resistance protein (MRP) and P-glycoprotein (P-gp) confer cancer cell resistance to chemotherapy. While both are ATP-binding cassette transporters, MRP also transports leukotriene and glutathione conjugates, indicating distinct functions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Multidrug resistance (MDR) in cancer is often mediated by ATP-binding cassette (ABC) transporters.
  • P-glycoprotein (P-gp) and multidrug resistance-associated protein (MRP) are key ABC transporters involved in MDR.
  • Despite structural differences, P-gp and MRP confer resistance to similar chemotherapeutic agents.

Purpose of the Study:

  • To review the structural and functional characteristics of MRP.
  • To elucidate MRP's role in conferring multidrug resistance.
  • To discuss the clinical relevance of MRP in drug-resistant cancers.

Main Methods:

  • Literature review of studies on MRP and P-gp.
  • Analysis of structural and functional data for MRP.

Related Experiment Videos

  • Examination of clinical data related to MRP expression and drug resistance.

    • Main Results:

    • MRP and P-gp share approximately 15% amino acid identity but are both ABC superfamily members.
    • MRP confers resistance to a similar profile of chemotherapeutic agents as P-gp.
    • MRP exhibits distinct functions, including the transport of cysteinyl leukotriene (LTC4) and glutathione conjugates.

    Conclusions:

    • MRP plays a significant role in multidrug resistance in cancer.
    • MRP's unique transport functions suggest roles beyond general drug efflux.
    • Understanding MRP is crucial for developing strategies against drug-resistant malignant diseases.