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[Principles and stakes of gene therapy]
P Moullier1, N Ferry, J M Heard
1Laboratoire de thérapie génique, CHU Hötel-Dieu, Nantes.
La Revue Du Praticien
|January 15, 1997
Abstract:
As the human genome sequencing expands and the molecular bases of diseases are better understood, the tools that allow gene packaging and transfer are available. Transferring a therapeutical gene becomes a reality and indeed more than 100 clinical protocols are currently exploring a variety of applications, from the inherited genetic diseases such as cystic fibrosis to the acquired ones such as cancer. Herein, we describe the different gene transfer strategies applied to animals and humans and we present the advantages and limitations of the currently available vectors which, today, represent the limiting factor for efficient gene therapy.