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Mitochondrial DNA mutations in Japanese detected by polymerase chain reaction--restriction fragment--single strand
M Tawata1, Y Ikegishi, E Iwase
1Third Department of Internal Medicine, Yamanashi Medical University, Japan. tawatam@res.yamanashi-med.ac.jp
Genetic Analysis : Biomolecular Engineering
|March 1, 1997
Abstract:
PCR-restriction fragment-SSCP (PCR-RF-SSCP) analysis of mitochondrial DNA by HhaI/HincII in Japanese revealed 46 polymorphic patterns. The determinations of nucleotide sequence of these 46 patterns revealed 56 mutations compared with the Cambridge Sequence.