Preventing epidemics with age-specific vaccination schedules
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1School of Statistical Science, La Trobe University, Bundoora, Victoria, Australia.
Abstract:
A method is proposed for computing the coverage required to prevent epidemics by age-specific vaccination schedules. The method applies in a very general setting and provides explicit expressions in many cases. It can accommodate vaccination doses administered at different ages, heterogeneity among individuals of different ages, a community structured into households, and waning of vaccine-induced immunity. A comparison of results for two specific community settings, with analogous parameter values, indicates that the immunity coverage required to prevent epidemics in a community of households is less than that required for a community of uniformly mixing individuals.
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