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[Opioid receptor types and dependence]
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|April 1, 1997
Summary
Opioid receptors mu and delta, but not kappa, cause physical and psychic dependence. Kappa receptor activation may suppress opioid dependence, offering potential therapeutic benefits.
Area of Science:
- Neuroscience
- Pharmacology
Context:
- Opioid receptors (mu, delta, kappa) are key in the central nervous system.
- Understanding their roles in dependence is crucial for pain management.
Purpose:
- To review the relationship between opioid receptor types and physical/psychic dependence.
- To explore the mechanisms underlying opioid-induced dependence.
Summary:
- Mu and delta opioid receptor agonists induce physical and psychic dependence.
- Kappa opioid receptor agonists do not produce dependence and may have aversive effects.
- Morphine dependence involves mu1/mu2 activation, affecting intracellular signaling pathways.
- Psychic dependence is linked to mesolimbic dopamine system activation by mu/delta1 agonists.
- Complex interactions exist: kappa activation suppresses dependence, delta potentiates it.
Impact:
- Kappa opioid receptor agonists may offer a way to manage or prevent opioid dependence.
- Insights into receptor interactions could lead to safer analgesics.
- Understanding these mechanisms is vital for treating opioid use disorder.