Rinderpest: at war with the disease of war

Rinderpest, the legendary cattle plague, has caused devastating losses for centuries and remains the biggest threat to sustainable livestock production in developing countries. Strenuous efforts are now being made to achieve global eradication of this viral disease, a goal made feasible through the use of attenuated live vaccines developed in the 1950s. Their use almost resulted in eradication in the 1970s but left several foci of disease from where the plague then re-emerged. Recent mass vaccination has resulted in the limitation of disease to parts of Africa, Pakistan, Afghanistan, the Middle East and India. Confirmation of the disease status of the countries has been aided by developments in serological techniques through exploitation of monoclonal antibodies (in Enzyme Linked Immunosorbent Assay-ELISA) and by advances in molecular biology such as in the use of polymerase reaction technologies (PCR). This has extended into the development of new recombinant vaccines. It is anticipated that eradication will be complete by the year 2010. This would be only the second example, after smallpox in man, of the eradication of a viral disease. The picture shows a scene of devastation during the Great Rinderpest Pandemic of 1889-1897 in South Africa. The disease swept through the African continent killing virtually all the cattle and wild ungulates.