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[The antinociceptive effect of tramal when combined with nonsteroidal anti-inflammatory preparations]
Abstract:
The antinociceptive effect of tramal and its combinations with nonsteroidal anti-inflammatory drugs (ortophen, indomethacin, naproxen, acetylsalicylic acid, and ibuprofen) was studied in 110 male albino rats on models of electric and thermal stimulation. Possessing their own antinociceptive activity, nonsteroidal anti-inflammatory drugs potentiated the analogous effect of tramal. In vitro tramal was intensively demethylated by the rat liver microsomal fraction. In therapeutic concentrations ortophen and naproxen suppressed the rate of tramal demethylation by the rat microsomes. The potentiating effect of nonsteroidal anti-inflammatory drugs in relation to tramal is apparently connected with the delay in its biotransformation and conversion to inactive metabolites.
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