[The effect of lithium chloride on the desynchronization of "reserpine-induced depression"]

Lithium chloride (5 mg/kg i.m. for 10 days in the morning but not in the evening) prevented effectively desynchronization of "reserpine depression" in mice and rats: the spectra and structure of the rhythms of behavioral parameters (open field), body temperature, content of serotonin and its metabolites in the brain and that of glucocorticoids in blood plasma were almost the same as those in intact animals; the circadian harmony of all parameters were correlated in the best manner and their mean circadian values were restored.