Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphogenesis: FGF branches out

H Skaer1

  • 1Department of Anatomy, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK. helen.skaer@anat.ox.ac.uk

Current Biology : CB
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic regulation of patterned tubular branching in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America·2006
Same author

Myoblast diversification and ectodermal signaling in Drosophila.

Developmental cell·2001
Same author

Coordinating cell fate and morphogenesis in Drosophila renal tubules.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2000
Same author

Cell polarity: Nailing Crumbs to the scaffold.

Current biology : CB·2000
Same author

Multiple signalling pathways establish cell fate and cell number in Drosophila malpighian tubules.

Developmental biology·2000
Same author

bloated tubules (blot) encodes a Drosophila member of the neurotransmitter transporter family required for organisation of the apical cytocortex.

Developmental biology·1999
Same journal

Proprioceptive cortical neurons implement optimal state estimation.

Current biology : CB·2026
Same journal

Coumarins link iron deficiency to TOR inhibition in plants.

Current biology : CB·2026
Same journal

Space-based monitoring of penguin diet links sea ice, food webs, and population change.

Current biology : CB·2026
Same journal

A global response contributes to tissue size robustness upon local induction of apoptosis.

Current biology : CB·2026
Same journal

Prebilaterian origin of monoaminergic signaling.

Current biology : CB·2026
Same journal

CLASP-dependent microtubule stabilization generates microtubule-based protrusive forces during Drosophila epithelial morphogenesis.

Current biology : CB·2026
See all related articles

Fibroblast growth factor (FGF) signaling guides cell movement during development. This study reveals a conserved mechanism where FGF signaling triggers cell detachment and migration in processes like tracheal branching.

Area of Science:

  • Developmental biology
  • Cell signaling
  • Molecular biology

Background:

  • Fibroblast growth factor (FGF) signaling plays a critical role in embryonic development.
  • Tissue-specific FGF receptors regulate key developmental processes such as organogenesis and pattern formation.

Purpose of the Study:

  • To investigate the conserved cellular mechanisms underlying fibroblast growth factor (FGF) signaling in developmental processes.
  • To identify common cellular responses to FGF signaling in tracheal branching and mesodermal patterning.

Main Methods:

  • Utilizing Drosophila melanogaster as a model organism.
  • Analyzing cellular behaviors including cell detachment and directed migration in response to FGF signaling.
  • Comparing findings across different species, from worms to mammals.

Related Experiment Videos

Main Results:

  • FGF signaling is crucial for tracheal branching and mesodermal patterning in Drosophila.
  • A conserved primary cellular response to FGF signaling involves cell detachment.
  • Directed cell migration is a key downstream effect of FGF-mediated cell detachment.

Conclusions:

  • The detachment and directed migration of target cells represent a conserved mechanism in FGF-mediated developmental processes.
  • This conserved mechanism highlights the fundamental role of FGF signaling in coordinating cell movements during embryogenesis across diverse species.