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[Cholestasis associated with ticlopidine]

A Díaz Fuenzalida1, H Valdés Socín, O Laudano

  • 1Departamento de Medicina Interna, Hospital de Clinicas José de San Martín, Universidad de Buenos Aires, Argentina.

Gastroenterologia Y Hepatologia
|March 1, 1997
PubMed
Summary
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Ticlopidine, a medication for peripheral arteriopathy, can cause cholestasis, a rare adverse effect. Discontinuation of the drug led to the resolution of cholestasis symptoms and normalization of liver function tests.

Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Internal Medicine

Background:

  • Cholestasis is a condition characterized by impaired bile flow.
  • Ticlopidine is an antiplatelet medication used to treat peripheral arteriopathy.
  • Adverse drug reactions can manifest as liver injury, including cholestasis.

Observation:

  • A 56-year-old male presented with jaundice, choluria, and itching.
  • Symptoms persisted for one month despite ticlopidine discontinuation one week prior to admission.
  • Liver biopsy revealed acinar cholestasis and portal inflammation.

Findings:

  • The patient's cholestasis was attributed to hypersensitivity to ticlopidine.
  • Discontinuation of ticlopidine led to a decrease in cholestasis parameters.

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  • Clinical and biochemical parameters normalized within 4 months post-discontinuation.

    • Implications:

    • This case underscores the importance of considering drug-induced cholestasis in patients presenting with these symptoms.
    • Early recognition and withdrawal of the offending agent, ticlopidine, are crucial for favorable outcomes.
    • Physicians should remain vigilant for rare adverse effects of commonly prescribed medications.